ABSTRACT
Introduction: Infection with SARS-CoV-2 is particularly hazardous in patients with cardiovascular pathology, diabetes or chronic lung disease. Arginine vasopressin (AVP), an antidiuretic hormone secreted in response to hemodynamic and osmotic disturbances plays a crucial role in maintenance of cardiovascular homeostasis. Copeptin has shown promising results regarding its utility in prediction of morbidity and mortality of COVID-19. Therefore, we conducted a meta-analysis to evaluate the role of copeptin in risk stratification in COVID-19. Methods: This study was designed as a systematic review and meta-analysis. We systematically searched the following databases: Scopus, Web of Science, PubMed, EMBASE, Cochrane Library through September 10th, 2022. Methodological quality was assessed using the Cochrane risk-of-bias tool. Results: Pooled analysis of four trials showed that mean copeptin plasma concentrations were higher in patients with severe course of COVID-19 than in patients with non-severe course of the disease (26.64 ± 13.59 vs. 16.75 ± 6.13, respectively;MD=9.39;95%CI: 1.38 to 17.40;I2=99%;p=0.02). Furthermore, higher copeptin concentrations in COVID-19 patients who died than in those who survived (13.25 ± 3.23 vs. 44.65 ± 26.92, respectively;MD=-31.40;95%CI:-42.93 to-19.87;p<0.001). Discussion: Results from the present meta-analysis revealed that increased copeptin plasma concentrations found in COVID-19 patients are associated with the severity of the disease. Copeptin may assist in early identification of COVID-19 progression and possibly in prediction of adverse outcomes, thus its use in risk stratification could be beneficial. Take-home message: Copeptin may assist in early identification of COVID-19 progression and possibly in prediction of adverse outcomes, thus its use in risk stratification could be beneficial. © 2022 by the authors.
ABSTRACT
Introduction: This study aims to explore how essential workers in Europe differed from the rest of the population in terms of their experiences of social life, access to services, mental well-being, and perceived benefits of the lockdown. Methods: This study used a descriptive analysis to evaluate the overall experiences of the essential workers in Europe. Data analyzed in this study is part of a larger global online cross-sectional survey conducted during April to November 2020 involving post-secondary staff, students and the general population (remote workers). Data of 19,794 participants are included in the current study, and analysis is based on a comparison of participants who self-identified as essential workers, with those who did not using the chi-square test. Results: Mean age was 34.5 years (SD =13.0) for essential workers and 30.2 years (SD =12.4) for the general population (remote workers). While 13.6% of all respondents were essential workers, the proportion was more among older ages (30 and above), females, and those who lived in suburbs. Overall, 46.8% of participants reported increased levels of stress during week 1-2 (51% of essential workers and 46.1% of the other participants, p<0.001). More essential workers reported their social life being great than the rest of the population (25.3% vs. 16.4%, p<0.001), and COVID-19 symptoms (13.6 vs 10.5%, p<0.001). In addition, fewer reported having troubled relationships (16.3% vs. 18.6%, p<0.001) or being able to do sufficient exercise (35.7% vs. 40.5%, p<0.001) than the general population (remote workers). Take-home message: The important role of essential workers during the pandemic cannot be overstated, yet their contributions, especially non-healthcare essential workers, have not been fully appreciated. © 2022 Parvin EFTEKHAR et al.
ABSTRACT
Introduction: During the COVID-19 pandemic, teleworking affected the mental well-being of nearly all strata of the population. Teachers, who were employed to teach online courses during lockdown have been psychologically distressed. The primary aim of the current study was to estimate the prevalence and differences in the Burnout Syndrome (BOS) symptomatology in the light of gender, work position, teaching role, and subject taught. As a secondary aim, differences in perceived wellbeing were estimated through the contribution of individual factors. Methods: An online cross-sectional survey was conducted from February-May 2021 to recruit a total of 361 teachers from all Italian regions. The Work-Life Balance scale, the Maslach Burnout Inventory, and an ad-hoc questionnaire with items on perceived physical well-being and perceived impact and difficulty in remote work were utilized. Predictors associated with burnout and its subscales were examined using linear regression analyses. Results: Burnout, measured as the co-existence of high emotional exhaustion (EE), high depersonalization (DP), and low personal accomplishment (PA) was revealed in 16.9% of teachers, while high EE, high DP, and low PA were respectively measured in 35.2%, 13.2% and 35.2% of the sample. Variables, such as gender, work position, teaching role, and subject taught were all significant for group differences in perceived well-being or BOS dimensions among teachers. Discussion: Our findings suggest that the implementation of occupational health programs and workplace health promotion programs for improving the mental well-being of teachers. In particular, a higher caution must be needed for implementing critical institutional changes, such as the wide and rapid adoption of telecommuting. Take-home message: Italian schoolteachers engaged in teleworking are exposed to a high risk of stress and burnout during the COVID-19 emergency. Implementing occupational health surveillance programs and workplace health promotions programs are needed to protect and improve teachers’ mental well-being. © 2022 by the authors.